The Chairman of the Doctoral Program in Bioengineering, Prof. Andrea Aliverti, is holding a yearly meeting to welcome the new PhD students. The purpose of the meeting is to provide useful information, also regarding administration issues.
The day of the meeting is November 15, 2018 and is announced by e-mail.
PhD Bioengineering Presentation - XXXIII - 2017
Seminars in Biomedical Engineering 2018-2019
Jan 31, 2019
14.00, Room Emilio Gatti, Politecnico di Milano, Via Golgi 39, Building 20
Prof. Roger G. Mark
Department of Electrical Engineering and Computer Science, MIT
The Impact of Open Sharing of Clinical Data
Abstract - The growth of new knowledge and technology flourishes in the presence of open sharing of data, and that progress is inhibited by keeping data private. This talk proposes a historical journey focusing on Prof. Mark's experience with automated arrhythmia analysis in the past, and with critical care data up to today.
: Image/signal processing Contacts:
Riccardo Barbieri email@example.com
Dec 05, 2018
Prof. Patrice Abry
17.00, Aula Alario, Politecnico di Milano, Via Golgi 39, Building 21, 2nd floor
CNRS Laboratoire de Physique. Ecole Normale Superieure de Lyon, Lyon, France
Self-Similarity and multifractality in Human brain activity: a wavelet based analysis of scale-free brain dynamics
Abstract - The temporal structure of macroscopic brain activity shows both oscillatory and scale-free dynamics. While the functional implication of neural oscillations has been largely demonstrated, the observation of scale-free dynamics has raised numerous questions, related to their nature and functional relevance. To address such issues, we propose here to enrich the characterization of scale-free brain activity both by the joint use of self-similarity and multifractality and by promoting a robust wavelet-based assessment procedure. To that end, human participants were recorded at rest and during task with magnetoencephalography~(MEG). Results show consistent infraslow (from $0.1$ to $1.5$ Hz) scale-free dynamics both at rest and during task. Further, the existence of a fronto-occipital gradient in self-similarity is reported, consistent with a hierarchy of temporal scales from sensory and associative to higher-order cortices. This gradient was further accentuated during task as compared to resting-state. Additionally, while little multifractality is reported at rest, significant increase were observed during task. A negative correlation across individuals in task vs rest variations between self-similarity and multifractality was also observed, mostly in the regions involved by the task. This concomitant decrease of self-similarity and increase of mulfractality %when switching from resting-state to task performance reflects a significant change from globally well-structured temporal dynamics at rest to a less globally structured activity during task, with significant transient and bursty non Gaussian locally scale-free structures. Altogether, the present study thus provides a refined characterization of scale-free dynamics in human brain activity.
Short biography - Patrice Abry is today « Research Director » for CNRS at Ecole Normale Supérieure de Lyon, France, here he is in charge of the « Signal, System and Physics » statistical signal processing research group, within the Physics department. He received the degree of Professeur-Agrégé de Sciences Physiques, in 1989, at Ecole Normale Supérieure de Cachan and the Ph. D. degree in physics and signal processing from the Claude-Bernard University, Lyon, France, in 1994. Patrice Abry has developed a long standing research program dedicated to the statistical multiscale analysis for the modeling of scale-free phenomena, with strong interest in researches integrating theoretical and applied developments in real-world applications, ranging from hydrodynamic turbulence to Internet traffic, heart rate variability, or neurosciences. He is the author of a book on wavelet, scale invariance and hydrodynamic turbulence and is also the coeditor of a book entitled Scaling, Fractals and Wavelets. Dr. Abry received the AFCET-MESR-CNRS prize for best Ph.D. in signal processing 1993–1994 and serves inn the IEEE SPS SPTM Committee since 2014. He is also an IEEE fellow.
perso.ens-lyon.fr/patrice.abry/ – firstname.lastname@example.org
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Dec 06, 2018
12.30, Sala Cardini (1st floor), Fondazione Don Gnocchi IRCCS S. Maria Nascente, Via Capecelatro 66 Milano
Prof. Clive Beggs
Leeds Beckett University, Leeds, United Kingdom
The venous connection: the role of veins in maintaining neurological health
Abstract - There is increasing evidence that the cerebral veins play an important role in regulating the haemodynamics and compliance of the intracranial space. Anomalies of the venous system have been linked with neurological diseases such as multiple sclerosis and Parkinson's disease, as well as migraine. However, the role that venous anomalies play in the pathology of neurological disease is poorly understood.
In his lecture Prof. Beggs will present his findings regarding the role that the venous system plays in regulating the biomechanics of the intracranial space, and will discuss the importance of this in maintaining neurological health.
Short biography - Clive Beggs is Professor of Applied Physiology at Leeds Beckett University. He is both a medical engineer and a physiologist, with a research interest in the biomechanics of the intracranial space, and vascular anomalies associated with neurological disease. He has published extensively on this subject, and has worked with many of the leading researchers in the field, both in Italy and the USA.
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Dec 18, 2018
15.30, Aula Alario, Politecnico di Milano, Via Golgi 39, Building 21, 2nd floor
Prof. Alessandra Balduini
Dipartimento di Medicina Molecolare, Università di Pavia
Laboratorio di Biotecnologie, IRCCS Fondazione San Matteo, Pavia
Silk biomaterials and bone marrow 3D modeling
Abstract - Bone marrow failure is the result of diseases, trauma, or cancer treatments, leading to a decreased production of blood cells and consequently, the necessity of blood transfusions. A number of studies point to the bone marrow niche as the core of blood cell production but with many interesting complex environmental factors for consideration. Thus, future advancement in the study of blood cell production will depend on the evolution of bioengineering techniques for reproducing physiologically relevant conditions in the bone marrow niche environment. To achieve this goal, the field is moving towards the reproduction of the characteristic features of the physiologic bone marrow microenvironment ex vivo by the use of relevant biomaterials and bioreactors, along with appropriate human cell sources. These models are expected to provide better mechanistic understanding and control of blood component production as well as insight towards the development of systems for the generation of functional blood cells necessary in transfusion and regenerative medicine to replace blood-donor supply. We have successfully developed different bioreactor systems, using silk fibroin, mimicking the bone marrow environment and thereby supporting haematopoiesis and megakaryopoiesis to generate significant numbers of human platelets ex vivo. Silk fibroin, derived from Bombyx mori silkworm cocoons, is a promising biomaterial for bone marrow tissue engineering because of its tunable architecture and mechanical properties, the capacity of incorporating labile compounds without loss of bioactivity and demonstrated ability to support platelet production without premature activation. Herein, our experience with bone marrow niche structure and composition, in combination with ex vivo models, in physiological and pathological conditions, will be discussed.
Short biography - Alessandra Balduini, MD, got her Medical Degree and Board of Clinical Biochemistry at the University of Pavia, Italy. After obtaining her Medical Degree she spent three years at the University of Indiana, Indianapolis, USA working, as post-doc, in the laboratory of Hal Broxmeyer, one of the pioneers of cord blood transplantation. Before creating her research group in 2007, she was a staff physician in the laboratory of Clinical Biochemistry, IRCCS San Matteo Foundation, and University of Pavia, Italy. In 2005-2006 she was Visiting Professor at Dana Farber Cancer Institute at Harvard Medical School. Since 2007 she has led a research group that is based in two different academic institutions: the Department of Molecular Medicine - University of Pavia, Italy and the Department of Biomedical Engineering - Tufts University, Boston, USA. The goal is to establish a cross-sectional program that integrates biological with bioengineering approaches to the study of haematopoiesis and bone marrow environment. Her research focuses on how the different components of the bone marrow microenvironment regulate platelet production. In 2011 she developed the groundwork for modeling human bone marrow by bioengineering a new 3D model made of porous silk that fully recreates the physiology of the living bone marrow niche environment. This system, completely redesigned in 2015 and 2017, is capable of successfully generating functional platelets ex vivo, offering new opportunities for producing blood components for clinical applications.
Scientific area: Regenerative medicine
Contacts: Sara Mantero email@example.com, Manuela Raimondi firstname.lastname@example.org
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Dec 18, 2018
17.00, Aula Alario, Politecnico di Milano, Via Golgi 39, Building 21, 2nd floor
Prof. Diego Mantovani
Laboratory for Biomaterials and Bioengineering, Laval University, Canada
Title: 3D triple human cell culture in bioreactor from collagen gel scaffolds: innovation in cosmetics, advanced in vitro models and regenerative medicine
Abstract - Over the last 50 years, biomaterials, prostheses and implants saved and prolonged the life of millions of humans around the globe. Today, nano-biotechnology, nanomaterials and surface modifications provides a new insight to the current problem of biomaterial complications, and even allows us to envisage strategies for the organ shortage. In this talk, creative strategies for mixing vascular cells and collagen-based materials will be targeted with the overall aim to envisage today how far innovation can bring tomorrow solutions for regenerative medicine. Collagen gel is a commonly used scaffold in vascular tissue engineering due to its biological properties including a high potential for supporting and guiding vascular cells in the regeneration process. With the aim to regenerate the vascular wall, the approach we deployed consisted in first reproducing the media, which provide the high elastic properties of the vessel wall, thus making it an essential and effective component for blood and nutrients transportation. Starting from an original method aimed to process collagen and smooth muscle cells (SMCs), we developed an endothelialised two layers collagen cell-based tubular scaffold. The external layer was composed of fibroblasts (FBs) and SMCs seeded within collagen. The middle layer was composed of SMCs seeded within collagen, and endothelial cells (ECs) were culture on the lumen of the construct. The construct was expected to provide vascular tissue remodeling due to cells/cells and cells/matrix interactions and to produce an engineered tissue with hierarchical structure close to that of blood vessel walls. It was also expected to provide a valid in vitro model for further studies of vascular patho-physiology. The middle and external layer were mold around a mandrel, directly in the bioreactor chamber. Then, the mandrel was removed and a ECs solution was perfused inside the lumen. The interaction between cells enhanced the matrix remodeling and the properties of the arterial construct resulted strongly improved. This shows that vascular cells tri-culture using collagen gel scaffold is a valid strategy for the regeneration of the vascular tissue. The overall take home message of this talk is aimed to show how 3D pluri-culture of appropriate material/cell/environment represent the today bottleneck in regenerative medicine and which are few of the strategies that have to be investigated to push forward innovation in the field.
Short biography - Holder of the Canada Research Chair in Biomaterials and Bioengineering for the Innovation in Surgery, professor at the Department of Materials Engineering at Laval University, adjunct director at the Division of Regenerative Medicine of the Research Center of the CHU de Québec, Diego Mantovani is a recognised specialist in biomaterials. At the frontier between engineering, medicine and biology, within his team, their works aim to improve the clinical performances of medical devices for functional replacement, and to envisage the next generations of biomaterials to develop artificial organs enhancing the quality of the life of patients. He has authored more than 260 original articles, holds 4 patents, and presented more than 190 keynotes, invited and seminar lectures worldwide in the field of advanced materials for biomedical applications. His H-Factor is 43 (Nov 2018) and his works received more than 7000 citations. In 2012, he was nominated Fellow of the International Union of Societies for Biomaterials Science & Engineering (FBSE) for his leadership and contribution to biomaterials for medical devices. He was Executive Co-Chair of the 10th World Biomaterials Congress 2016. He is advisor of three medical devices consortium in the Americas, Asia and Europe.
Regenerative medicine Contacts:
Sara Mantero email@example.com,
Gabriele Candiani firstname.lastname@example.org
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